LOL!!!
A pot hole could blow it out, theoretically. But, a pot hole large enough to blow a decent(re: Goodyear) air-bag would also take out the tire, rim and spindle. And you'd have to be running triple digits.
The reason air-ride front ends aren't popular is two-fold. First, they're expensive to spec and even more expensive to retrofit. Second, the ride on the early units was so soft it left drivers with a very unsettling feeling. Going around corners, clover-leafs, etc. left you feeling like the truck was trying to lay down.
The new systems have a more solid feel while softening the ride.