Most of the mechanics that I know that work on them say they seem to do better in vocational or regional (gravel trucks, local delivery trucks, etc) applications, where engine loads and speed varies greatly, than in less long haul type trucks where you set the cruise and go at a steady pace.
That being said RV'ers don't put on the huge miles like truckers do, so you probably have a much reduced chance of problems. Removing the EGR system, especially if it as simple as blocking a pipe, is a cheap, easy way to reduce possible problems.
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